• Product Name:Benfotiamine
  • Molecular Formula:C19H23N4O6PS
  • Purity:99%
  • Molecular Weight:466.455
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Product Details;

CasNo: 22457-89-2

Molecular Formula: C19H23N4O6PS

Appearance: White crystalline powder

Hot Sale Price High Purity Benfotiamine 22457-89-2 Crystalline Powder

  • Molecular Formula:C19H23N4O6PS
  • Molecular Weight:466.455
  • Appearance/Colour:White crystalline powder 
  • Vapor Pressure:2.55E-23mmHg at 25°C 
  • Melting Point:165 °C 
  • Refractive Index:1.645 
  • Boiling Point:745.1 °C at 760 mmHg 
  • PKA:1.84±0.10(Predicted) 
  • Flash Point:404.4 °C 
  • PSA:191.05000 
  • Density:1.444 g/cm3 
  • LogP:3.84720 

Benfotiamine(Cas 22457-89-2) Usage

Chemical Properties





S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.


ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.

Manufacturing Process

28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).

Therapeutic Function


General Description

S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine?contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.

Biochem/physiol Actions

S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.


22457-89-2 Relevant articles

Benfotiamine related substance, preparation method, application and detection method


, (2021/05/12)

The invention discloses a benfotiamine r...

Benfotiamine related substance as well as preparation method, application and detection method thereof


Paragraph 0027-0029, (2021/05/12)

The invention discloses a benfotiamine r...

A method for the production of thiamine benzene phosphorus


, (2017/01/12)

The invention relates to a production me...

A Thiamin benzene phosphorus compound and its preparation and its pharmaceutical compositions containing the compounds


Paragraph 0065-0071, (2017/03/08)

The invention relates to a benfotiamine ...

22457-89-2 Process route



Conditions Yield
Thiamin-phosphat*HCl in wss. NaOH bei pH=10, Na-Benzoyl-thiosulfat;
thiamine monophosphate chloride

thiamine monophosphate chloride

benzoyl chloride

benzoyl chloride

S-[2-[[(4-amino-2-methyl-5 pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester

S-[2-[[(4-amino-2-methyl-5 pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester

Conditions Yield
thiamine monophosphate chloride; With water; sodium hydroxide; at 0 - 15 ℃; for 1h; pH=12.5 - 13;
benzoyl chloride; at -1 - 6 ℃;
With hydrogenchloride; at 0 - 10 ℃; for 3h; pH=3.8 - 4.1;

22457-89-2 Upstream products

  • 10023-48-0

    2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate

  • 98-88-4

    benzoyl chloride

  • 59-43-8

    vitamin B1

  • 67-03-8

    Thiamine hydrochloride

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