1786-81-8
- Product Name:Propitocaine hydrochloride
- Molecular Formula:C13H20N2O.HCl
- Purity:99%
- Molecular Weight:256.776
Product Details;
CasNo: 1786-81-8
Molecular Formula: C13H20N2O.HCl
Appearance: White or off white crystalline powder
Good Manufacturer Fast Delivery Propitocaine hydrochloride 1786-81-8 In Bulk Supply
- Molecular Formula:C13H20N2O.HCl
- Molecular Weight:256.776
- Appearance/Colour:White or off white crystalline powder
- Vapor Pressure:2.05E-05mmHg at 25°C
- Melting Point:168-170oC
- Boiling Point:361.6 °C at 760 mmHg
- Flash Point:134.3 °C
- PSA:41.13000
- LogP:3.58750
Propitocaine hydrochloride(Cas 1786-81-8) Usage
Chemical Properties |
White Solid |
Uses |
antibacterial |
Definition |
ChEBI: The monohydrochloride salt of prilocaine. |
Brand name |
Citanest (AstraZeneca). |
Biological Functions |
Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB+++ to methemoglobin (HB+++. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin. |
Contact allergens |
Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream. |
InChI:InChI=1/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
1786-81-8 Relevant articles
A method for preparing prilocaine hydrochloride
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Paragraph 0045-0047, (2017/03/14)
The invention relates to a synthetic pro...
1786-81-8 Process route
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107-10-8,42939-71-9
propylamine
-
-
7623-09-8
2-chloropropionyl chloride
-
-
95-53-4
o-toluidine
-
-
1786-81-8
prilocaine hydrochloride
Conditions | Yield |
---|---|
2-chloropropionyl chloride; o-toluidine;
In
dichloromethane;
at 20 - 22 ℃;
for 2.5h;
propylamine;
With
hydrogenchloride;
In
water;
for 7h;
pH=1 - 2;
Concentration;
Temperature;
Reflux;
|
95.05% |
-
-
721-50-6,14289-31-7
prilocaine
-
-
1786-81-8
prilocaine hydrochloride
Conditions | Yield |
---|---|
With
hydrogenchloride;
In
water; ethyl acetate;
pH=1;
|
96% |
1786-81-8 Upstream products
-
propylamine
-
2-chloropropionyl chloride
-
o-toluidine
-
prilocaine
1786-81-8 Downstream products
-
o-toluidine
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CJC-1295
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