5086-74-8
- Product Name:Tetramisole hydrochloride
- Molecular Formula:C11H12N2S.HCl
- Purity:99%
- Molecular Weight:240.757
Product Details;
CasNo: 5086-74-8
Molecular Formula: C11H12N2S.HCl
Appearance: white to pale cream crystalline powder
Global Trade Tetramisole hydrochloride 5086-74-8 Purity: ≥99% In Medicine
- Molecular Formula:C11H12N2S.HCl
- Molecular Weight:240.757
- Appearance/Colour:white to pale cream crystalline powder
- Melting Point:266-267 °C(lit.)
- Boiling Point:344.4 °C at 760 mmHg
- Flash Point:162.1 °C
- PSA:40.90000
- LogP:2.32160
Tetramisole hydrochloride(Cas 5086-74-8) Usage
Chemical Properties |
Tetraimidazole hydrochloride is a white to pale cream crystalline powder, bitter and astringent, easily soluble in water , Methanol, slightly soluble in ethanol, insoluble in acetone. acid solutions are stable; however, hydrolysis occurs under alkaline conditions. The rate of hydrolysis increases with pH and temperature. It is used as levamisole intermediate, anthelmintic drug. |
Uses |
Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. It is suitable for inhibition of various alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor)(Intestinal alkaline phosphatases are only slightly inhibited.). Tetramisole has biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator. |
Definition |
ChEBI: Tetramisole hydrochloride is an organic molecular entity. It is a broad-spectrum veterinary anthelmintic with high efficiency and low toxicity. |
Application |
Tetramisole is an alkaline phosphatase inhibitor. It is a racemic mixture of (+) and (-) isomers. The (-) isomer (levamisole) accounts for most of the biological activity of tetramisole.Tetramisole has been used to inhibit alkaline phosphatase in the effective range of 0.4 – 2 mM. Inhibition of intestinal alkaline phosphate requires higher concentrations. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.Tetramisole is an anthelminthic agent used in veterinary applications to treat helminth or worm infections. |
Brand name |
Ergamisol (Janssen). |
in vitro |
Tetramisole hydrochloride at 67.5 mg/kg is 88.8% effective against immature and 99.7% effective against adult Libyostrongylus douglassi of the ostrich. A dose of up to 408 mg/kg tetramisole hydrochloride had no adverse effects on young birds but at 529 mg/kg was lethal to both chicks and adult ostriches. The efficacy of pyrantel tartrate was erratic. At 50 - 60 mg/kg it was 72.3% effective against immatures and 50.2% effective against adult worms. At 100 mg/kg it fell to 43.6% against immature, but rose to 77.3% against adult worms. Pyrantel tartrate at 100 mg/kg caused the death .of three out of four chicks. The macroscopic lesions of the disease ""vrotmaag"" caused by L. douglassi are descriptionbed as well as some of the other pathological lesions observed at autopsy. |
Mode of action |
Tetramisole HCl inhibits parasitic worm growth by acting as an agonist to nicotinic acetylcholine receptors leading to paralysis. The mechanism of action for anticancer activity is unknown. |
InChI:InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H
5086-74-8 Relevant articles
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Manufacture of tetramisole
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5086-74-8 Process route
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5086-74-8,74191-78-9
tetramisole hydrochloride
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5036-02-2
Tetramisole
Conditions | Yield |
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phosphorous pentasulfide
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phosphorous pentasulfide
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65329-72-8
1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one
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5086-74-8,74191-78-9
tetramisole hydrochloride
Conditions | Yield |
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With
hydrogenchloride; sodium hydroxide;
In
ethanol; chloroform; toluene;
|
|
With
hydrogenchloride; sodium hydroxide;
In
ethanol; chloroform; toluene;
|
5086-74-8 Upstream products
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pyrographite
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1-(2-acetoxy-ethyl)-4-phenyl-imidazolidin-2-one
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1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one
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1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one
5086-74-8 Downstream products
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2-Imino-3-styryl-thiazolidin
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R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole
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Tetramisole
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1-(2-Mercapto-ethyl)-4-phenyl-imidazolidin-2-one
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